Description
Melanotan I, also known as Afamelanotide, is a synthetic linear peptide analogue of the naturally occurring Ξ±-melanocyte-stimulating hormone (Ξ±-MSH). It consists of 13 amino acids and demonstrates high affinity for the melanocortin-1 receptor (MC1R), a receptor pathway primarily associated with skin pigmentation and photoprotection. In laboratory research settings, Melanotan I has been studied for its potential to stimulate melanin production, enhance UV resistance, and modulate certain biological processes linked to oxidative stress and DNA damage repair.
Important Note
Melanotan I is not approved for human consumption, medical use, or diagnostic purposes. It is supplied strictly for laboratory research only. Handling should be performed by qualified professionals in an appropriate researchΒ setting.
Dosage Reference Chart
| Form | Suggested Research
Concentration |
Example Preparation | Notes |
| Lyophilized Powder | 10 mg per vial | Reconstitute with sterile or
bacteriostatic water |
Store dry at β20Β°C until
use |
| Reconstituted Solution | Β 200β500 Β΅g/mL | Dissolve to target concentration for
experiments |
Stable at 2β8Β°C for 2β3
weeks; do not freeze once reconstituted |
| Experimental
Dosing (animal studies, literature-based)* |
Variable by study | Adjust according to study design | Preclinical models only |
Features & Properties
-Synthetic 13-amino-acid peptide analogue of Ξ±-MSH
-Selective MC1R receptor agonist
-Investigated for its role in melanogenesis, photoprotection, and oxidative stress modulation
-Supplied as a lyophilized powder for stability and extended shelf life
-Manufactured and sealed under sterile, research-grade conditions
Storage & Stability
β Lyophilized peptide: Stable for up to 24 months at β20Β°C.
β Reconstituted solution: Stable for 2β3 weeks at 2β8Β°C.
β Avoid repeated freezeβthaw cycles.
β οΈ Research Use Disclaimer
β’ For laboratory research use only
β’ Not approved for human consumption, medical use, or diagnostic purposes
β’ Handling should be performed by qualified professionals in controlled environments
β’ Store securely and keep out of reach of children
β’ Do not handle during pregnancy or breastfeeding





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